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Comparison of term and preterm labor procalcitonin and leukocyte cell volume, conductivity and light scatter (VCS) parameters in order to demonstrate the impact of inflammation on the triggering mechanisms of preterm uterin contractions
Author(s) -
Unal Canan,
Karatas Esra,
Fadıloglu Erdem,
Portakal Oytun,
Beksac Mehmet Sinan
Publication year - 2020
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.14216
Subject(s) - medicine , procalcitonin , white blood cell , preterm labor , inflammation , monocyte , lymphocyte , gastroenterology , immunology , obstetrics , sepsis , pregnancy , gestation , biology , genetics
Abstract Aim Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters of neutrophil, monocyte and lymphocyte, procalcitonin (PCT) and white blood cell count (WBC) during term and preterm labor to evaluate the impact of inflammation on the triggering mechanisms of uterine contractions. Methods This study is consisted of 16 preterm and 60 term pregnancies at the beginning of the first stages of the labor. Leukocyte VCS parameters, PCT plasma levels and WBC count were evaluated. Results We could not demonstrate statistically significant difference in between leukocyte VCS parameters in preterm and term deliveries ( P ˃ 0.050 for all). WBC counts were 10.6 and 11.8 × 10 3 /μL in the preterm and term groups respectively ( P = 0.270). PCT levels were 0.04 and 0.03 ng/mL for preterm and term pregnancies ( P = 0.062). Conclusion Inflammation related markers such as leukocyte VCS parameters, PCT values and WBC count does not differentiate at the first stage of labor in preterm and term deliveries. These variables do not seem to have a prominent role at the biological events behind preterm contractions.