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Comparison of the efficacy of diegnogest and levonorgestrel‐releasing intrauterine system after laparoscopic surgery for endometriosis
Author(s) -
Lee Ki H.,
Jung Ye W.,
Song Soo Y.,
Kang Byung H.,
Yang Jung B.,
Ko Young B.,
Lee Mina,
Han Hye Y.,
Yoo Heon J.
Publication year - 2018
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/jog.13703
Subject(s) - dienogest , medicine , endometriosis , discontinuation , levonorgestrel , surgery , laparoscopy , pelvic pain , laparoscopic surgery , urology , gynecology , population , family planning , environmental health , research methodology
Abstract Aim To compare the efficacy between dienogest and levonorgestrel‐releasing intrauterine system (LNG‐IUS) after laparoscopic surgery for endometriosis. Methods A total of 285 women were diagnosed as endometriosis by laparoscopy between 2011 and 2015. Patients were grouped into no treatment ( n = 83), treatment with dienogest ( n =130) and treatment with LNG‐IUS ( n =72) after laparoscopic surgery. The changes of the pain scores were checked at 6, 12 and 24 months after the surgery, and the rates of disease recurrence and treatment discontinuation rate were determined. Results The participants' mean age was 38.9 years (range 21–54 years). The mean age of LNG‐IUS group (43.7 years) was significantly higher than the no treatment and dienogest groups (39.3 vs 33.9 years, respectively). At 6 and 12 months, the median pain scores in treatment (dienogest and LNG‐IUS) groups were significantly lower than control group. Both treatment groups had significantly lower recurrence rate than control group (3.8% and 9.7%, respectively, vs 32.5%, P =0.001). No significant difference was found in the recurrence rate between the two treatment groups ( P =0.461). Patients in the LNG‐IUS group showed lower rate of discontinuation due to complication (27.8%) than those in dienogest group (35.6%, P =0.010). Conclusion LNG‐IUS treatment in the patients with endometriosis is effective for postoperative pain control and preventing recurrence, however, the LNG‐IUS group is older, it is difficult to compare the efficacy between dienogest and LNG‐IUS in present study.