Premium
Evaluation of tacrolimus and mycophenolic acid removal by simultaneous continuous hemodiafiltration and plasma exchange in a lung transplant patient
Author(s) -
Goto Yuri,
Nakajima Takahiro,
Suzuki Tatsuya,
Yamazaki Shingo,
Suzuki Takaaki,
Yoshino Ichiro,
Ishii Itsuko
Publication year - 2021
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13286
Subject(s) - mycophenolic acid , tacrolimus , medicine , lung , plasma concentration , surgery , urology , anesthesia , transplantation , pharmacology
Abstract What is known and objective The removal rates of tacrolimus (TAC) and mycophenolic acid (MPA) by simultaneous plasma exchange (PE) and continuous hemodiafiltration (CHDF) are not clear. Case summary We evaluated the removal rates of TAC and MPA by PE and CHDF started simultaneously 5 hours after administration in a lung transplant patient. TAC was not removed. MPA was transferred into the PE effluent, but the total amount in the effluent was only 1% of the dosage. What is new and conclusion TAC and MPA were less likely to be removed by PE and CHDF initiated 5 hours after administration.