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Gender specific IOP measurement using induced corneal vibration analysis ‐ a multicenter clinical trial
Author(s) -
Bitoun P.,
Bouafia K.,
Khoueir Z.,
Haouchine B.,
Hammoud S.,
Chapelle P.,
Chambard J.P.,
Jourot P.,
Lachkar Y.,
Benzacken L.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0373
Subject(s) - medicine , keratometer , ophthalmology , glaucoma , intraocular pressure , cornea
Purpose Novel non‐contact, non‐invasive Vibration Tonometry using analysis of induced corneal vibrations and their correlation to GAT IOP was tested in a large multicenter clinical trial. Methods 470 eyes in 236 volunteers from various ethnic origins at Paris area hospital eye clinic and Glaucoma Institute were studied. History, vibration tonometry measurements in triplicate GAT , NIDEK air puff IOP , refractometry, keratometry and non‐contact pachymetry. Algorithm discovery was performed by random draw splitting runs into a discovery sample and a separate validation sample performed 10 times separately in men and women Results In 236 patients, 34.6% of eyes had glaucoma, 51% of which women. 1311/1772 (76%) vibration tonometry measurements were in correct position. Population aged 20–92 yo with 48.7% females with mean of 62.1(± 13.5) in women and 62.5 (± 12.7) in men. CCT mean was 531.2 μ (± 37.3) in women and 534.8 μ (± 38.5) in men. 207 patients AL mean was 23.29 mm (± 1.68) in women and 23.73 mm (± 1.68) in men. GAT IOP ranged from 5.3 to 34 mm Hg, mean was 15.2 mm Hg (± 3.1) in women and 15.2 (± 3.52) in men ‐No significant differences. No adverse events during or post trial. Algorithm for women yielded 98.6% of IOP mean within 5 mm Hg of mean GAT IOP and 86% within 3 mm Hg. For men 96.4% of IOP mean was within 5 mm Hg of mean GAT IOP and 84.2% within 3 mm Hg from GAT IOP mean. Using the mean of 2 closest measures was used . Conclusions Current algorithm shows no influence of CCT on IOP . Gender Specific algorithm concurrs with previous publications of different corneal hysteresis (lower) in women. Vibration tonometry is a valuable method for measurement of IOP without contact with precision and reproducibility independently of CCT . It may be a valuable tool for IOP measurement in thin and surgical corneas.