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Update in management of optic nerve glioma (part 2)
Author(s) -
Parsa C.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0181
Subject(s) - radiation therapy , glioma , modalities , medicine , modality (human–computer interaction) , optic nerve , treatment modality , cancer research , bioinformatics , neuroscience , oncology , surgery , biology , computer science , ophthalmology , social science , human–computer interaction , sociology
Summary Significant controversy exists in the treatment of optic nerve glioma because of the absence of evidenced‐based trials demonstrating efficacy for various treatments administered over the years, from radiation therapy to various chemotherapeutic regimens and combinations thereof. Elements of tumor biology will be discussed along with fundamental properties of anti‐mitotic regimens administered to date, as well as newer agents proposed targeting protein synthesis rather than DNA replication. Discussion of how tumor suppressor gene status ( NF 1) should be taken into consideration when deciding upon a treatment modality will also be discussed. Novel vision sparing surgical modalities applicable to NF 1‐associated orbital gliomas in particular will be reviewed.