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Comparison of FD‐OCT mGCC and pRNFL for the early detection of glaucoma
Author(s) -
ROLLE T,
BRIAMONTE C,
CURTO D,
GRIGNOLO FM
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.364.x
Subject(s) - glaucoma , medicine , ophthalmology , receiver operating characteristic , retinal , intraocular pressure , optometry
Abstract Purpose To evaluate and compare the Glaucoma detection ability of macular GCC thickness with that of peripapillary RNFL measured by FD‐OCT (RTVue 100. Optovue Inc, CA) in patients with Preperimetric Glaucoma (PPG) and Perimetric Glaucoma (PG) at early stage according to Hodapp‐Parrish‐Anderson classification. Methods 89 patients (178 eyes: 70 PPG, 56 PG and 52 healthy) were enrolled in this cohort study. Each subject underwent complete ophthalmic examination and imaging of mGCC, pRNFL, ONH and 3D disk using RTVue 100. The means of each parameters were compared with ANOVA test. ROC curves were generated for different GCC and RNFL parameters. For both GCC and RNFL protocols the OR‐logical disjunction (Boolean Logic Operator) was calculated. Areas under the ROC curves (AUC) of each parameter were compared ( Delong test). Results The AUCs for Average, Superior, Inferior RNFL were not significantly different (0.72, 0.71, 0.75 respectively): the largest AUC for RNFL parameters was that of RNFL OR (0.79). Average, Superior, Inferior, FLV % GCC (0.74, 0.71, 0.77, 0.76 respectively) were not significantly different from each other and from RNFL AUCs. The largest AUC was that of GLV% GCC (0.81) which is significantly higher than both RNFL and GCC parameters AUCs. Even for the GCC scan, the GCC OR AUC (0.78) was better than others parameters, exception for GLV%. Conclusion We found that GLV% had higher diagnostic accuracy than the simple average for the diagnosis of glaucoma: this must mean that, in some cases, pattern parameters are more sensitive or more specific. The computation of Boolean OR Operator have been found to boost diagnostic accuracy. In summary, analysis of GCC loss pattern further boosted diagnostic accuracy of RNFL measurements.