Premium
2011 International Melanoma Congress
Author(s) -
Bowden, N. A.,
Ashton, K. A.,
Avery-Kiejda, K. A.,
Zhang, X. D.,
Hersey, P.,
Scott, R. J.
Publication year - 2011
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/j.1755-148x.2011.00909.x
Subject(s) - melanoma , medicine , cancer research , political science , computational biology , biology
We have confirmed that the GGR regulators, BRCA1 and PCNA, are induced in normal cellular response to cisplatin induced DNA damage, but there is complete absence of induction of these regulators in melanoma cell lines. In addition, we identified highly significant overlap of transcript expression in melanoma cell lines after cisplatin treatment with transcripts highly correlated with the DNA doublestrand break repair genes BRCA1, BRCA2, ATM and CHEK2. Finally, we confirmed complete lack of induction of XPB in melanoma cell lines and a significant overlap of transcript expression with XPB deficient cells after UVR