An Assay for the Quantitation of Photofrin in Tissues and Fluids | Zendy

Bellnier David A. | Zendy; Greco William R. | Zendy; Parsons John C. | Zendy; Oseroff Allan R. | Zendy; Kuebler Alex | Zendy; Dougherty Thomas J. | Zendy

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An Assay for the Quantitation of Photofrin in Tissues and Fluids

Author(s) -

Bellnier David A.,

Greco William R.,

Parsons John C.,

Oseroff Allan R.,

Kuebler Alex,

Dougherty Thomas J.

Publication year - 1997

Publication title -

photochemistry and photobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.818

H-Index - 131

eISSN - 1751-1097

pISSN - 0031-8655

DOI - 10.1111/j.1751-1097.1997.tb08649.x

Subject(s) - biological fluids , porphyrin , fluorescence , dissolution , chemistry , standard curve , chromatography , biochemistry , optics , organic chemistry , physics

A method for determining the concentration of Photofrin in tissues and biological fluids was developed. The procedure is based on the dissolution of biological material with Solvable a commercially available tissue so‐lubilizer, followed by porphyrin‐specific fluorescence detection and measurement. It was found necessary to use a quadratic standard curve for the estimation of unknown Photofrin concentrations. While this method is limited to compounds that are stable in strong base, it has the advantages of being sensitive, rapid and low cost .

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