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Photorepair of Ultraviolet Radiation (UVR)‐lnduced Pyrimidine Dimers in Lens Epithelial DNA of Monodelphis domestica
Author(s) -
Tafoya Gregory B.,
Gale James M.,
Ley Ronald D.
Publication year - 1997
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1997.tb01887.x
Subject(s) - pyrimidine dimer , micrococcus luteus , lens (geology) , dna , pyrimidine , photolyase , dna damage , biology , monodelphis domestica , marsupial , endonuclease , microbiology and biotechnology , chemistry , ultraviolet radiation , dna repair , biophysics , biochemistry , escherichia coli , gene , radiochemistry , zoology , paleontology
— The repair of UV radiation‐induced pyrimidine dimers has been measured in lens epithelial DNA of the marsupial Monodelphis domestica using a pyrimidine dimerspecific endonuclease from Micrococcus luteus. Approximately 40% of the initially induced dimers were repaired during 90 min exposures to photoreactivating light. This capacity of the lens epithelium to photorepair pyrimidine dimers may provide a means with which to determine whether pyrimidine dimers in lens epithelial DNA are involved in UV radiation‐induced pathologic changes of the lens.
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