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VISIBLE LIGHT ANAEROBIC PHOTOCONVERSION OF TYROSINE SENSITIZED BY RIBOFLAVIN. CYTOTOXICITY ON MOUSE TUMORAL CELLS
Author(s) -
Silva Eduardo,
Fürst Sonia,
Edwards Ana M.,
Becker M. Ines,
Ioannes Alfredo E. De
Publication year - 1995
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1995.tb02406.x
Subject(s) - cytotoxicity , anaerobic exercise , chemistry , tyrosine , riboflavin , photochemistry , visible spectrum , in vitro , absorption (acoustics) , biochemistry , biology , materials science , physiology , optoelectronics , composite material
The anaerobic phototransformation of tyrosine under visible light sensitized by riboflavin is reported. The cytotoxicity of the anaerobic photoproducts on in vitro ‐cultured myeloid mouse tumoral cells was demonstrated. A radical mechanism is proposed. Dityrosine was identified as one of the main anaerobic photoproducts by using absorption, emission and 1 H‐NMR spectra.