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THE USE OF INTERNALIZABLE DERIVATIVES OF CHLORIN E 6 FOR INCREASING ITS PHOTOSENSITIZING ACTIVITY
Author(s) -
Akhlynina Tamara V.,
Rosenkranz Andrey A.,
Jans David A.,
Gulak Pavel V.,
Sererryakova Natalia V.,
Sobolev Alexander S.
Publication year - 1993
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1993.tb04901.x
Subject(s) - photosensitizer , chlorin , chemistry , internalization , photodynamic therapy , trypan blue , intracellular , conjugate , receptor , biophysics , biochemistry , cell , photochemistry , biology , organic chemistry , mathematical analysis , mathematics
Abstract Experiments with human hepatoma PLC/PRF/5 cells and human embryo skin fibroblasts involving the use of three different tests (colony formation, Trypan blue exclusion, labeled thymidine incorporation) have demonstrated a significantly higher photosensitizing activity of chlorin e 6 conjugates with internalizable ligands as compared to that of chlorin e 6 itself. Receptor‐mediated internalization of chlorin e 6 conjugates ensures a greater photosensitization of cells than binding of those conjugates to cell surface receptors. The suitability of such conjugates that permit the delivery of a photosensitizer to sensitive intracellular targets is discussed.