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Humanized mice for the study of type 1 and type 2 diabetes
Author(s) -
Greiner Dale L.,
Brehm Michael A.,
Hosur Vishnu,
Harlan David M.,
Powers Alvin C.,
Shultz Leonard D.
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06318.x
Subject(s) - type 2 diabetes , immune system , in vivo , diabetes mellitus , islet , type 1 diabetes , medicine , immunology , biology , endocrinology , microbiology and biotechnology
The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.