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Molecular mechanisms of Barrett's esophagus and adenocarcinoma
Author(s) -
Dvorak Katerina,
Goldman Aaron,
Kong Jianping,
Lynch John P.,
Hutchinson Lloyd,
Houghton Jean Marie,
Chen Hao,
Chen Xiaoxin,
Krishnadath Kausilia K.,
Westra Wytske M.
Publication year - 2011
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2011.06062.x
Subject(s) - esophagus , barrett's esophagus , adenocarcinoma , metaplasia , intestinal metaplasia , cancer research , transcription factor , gastroenterology , medicine , chemistry , dysplasia , cancer , gene , biochemistry
The following on molecular mechanisms of Barrett's esophagus and adenocarcinoma contains commentaries on the mechanism of bile and gastric acid induced damage; the roles of BMP‐4 and CDX‐2 in the development of intestinal metaplasia; the transcription factors driving intestinalization in Barrett's esophagus; the contribution of bone marrow to metaplasia and adenocarcinoma; activation and inactivation of transcription factors; and a novel study design targeting molecular pathways in Barrett's esophagus.