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Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke
Author(s) -
Conrado Daniela J.,
Gonzalez Daniel,
Derendorf Hartmut
Publication year - 2010
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2010.05729.x
Subject(s) - pharmacokinetics , drug , stroke (engine) , pharmacology , absorption (acoustics) , medicine , psychological intervention , materials science , physics , psychiatry , composite material , thermodynamics
Absorption is a critical component of the pharmacokinetics for solid dosage forms administered orally. Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug‐specific properties, formulation issues, and (patho)physiological changes in the gastrointestinal tract must be considered. First‐pass metabolism in the gut and/or liver can dictate the extent to which a drug reaches the systemic circulation. Drug‐metabolizing enzymes in the gut and liver are very susceptible to inhibition by other drugs, increasing the risk of drug interactions. In this paper, we will discuss absorption‐related issues for solid dosage forms used in the management of stroke patients.