The Relationship between Inflammation and Regeneration in the MRL Mouse | Zendy

HeberKatz Ellen | Zendy; Gourevitch Dmitri | Zendy

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The Relationship between Inflammation and Regeneration in the MRL Mouse

Author(s) -

HeberKatz Ellen,

Gourevitch Dmitri

Publication year - 2009

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1111/j.1749-6632.2009.04499.x

Subject(s) - proteases , matrix metalloproteinase , regeneration (biology) , wound healing , inflammation , microbiology and biotechnology , tissue remodeling , biology , immunology , medicine , genetics , enzyme , biochemistry

The matrix metalloproteinases (MMPs) have been implicated in the regenerative response in amphibians and various mammalian models of regeneration. The neutrophil response is known to bring MMPs and other proteases to the wound to promote bacterial elimination and tissue remodeling. These issues in relation to what is occurring in the MRL mouse model of regeneration/wound healing are discussed, followed by speculation as to their possible relevance for examples of the putative scarless wound healing described by some medical anthropologists and clinicians.

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