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Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration
Author(s) -
Kim Dohoon,
Tsai LiHuei
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04105.x
Subject(s) - neurodegeneration , dna damage , cell cycle , chromatin , microbiology and biotechnology , biology , neuroscience , cell cycle checkpoint , dna , dna repair , cell , genetics , medicine , disease , pathology
Aberrant cell cycle activity and DNA damage have been observed in neurons in association with various neurodegenerative conditions. While there is strong evidence for a causative role for these events in neurotoxicity, it is unclear how they are triggered and why they are toxic. Here, we introduce a brief background of the current view on cell cycle activity and DNA damage in neurons and speculate on their relevance to neuronal survival. Furthermore, we suggest that the two events may be triggered in common by deregulation of fundamental processes, such as chromatin modulation, which are required for maintaining both DNA integrity and proper regulation of cell cycle gene expression.