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Relaxin Receptor LGR7 (RXFP1) Is Regulated by Estrogen
Author(s) -
Maseelall Priya,
Gardner Jeff,
Wojtczuk Andrea,
Weiss Gerson,
Goldsmith Laura T.
Publication year - 2009
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2009.04048.x
Subject(s) - relaxin , estrogen , endocrinology , estrogen receptor , medicine , messenger rna , receptor , in vitro , biology , microbiology and biotechnology , chemistry , hormone , biochemistry , gene , cancer , breast cancer
Estrogen regulates LGR7 (RXFP1) mRNA expression in an in vitro model of human term pregnancy cervix that utilizes lower uterine segment fibroblasts. LGR7 mRNA levels were increased by estradiol to mean levels of 152%± 5.9% above those in untreated control cells. Therefore, estradiol may amplify relaxin's actions in the cervix.