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Genetics of Hypertension: The Adducin Paradigm
Author(s) -
BIANCHI GIUSEPPE,
TRIPODI GRAZIA
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb07280.x
Subject(s) - mechanism (biology) , genetics , disease , biology , bioinformatics , medicine , philosophy , epistemology
A bstract : The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na‐K pump; and (4) future directions.