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The Na + /Ca 2+ Exchange Molecule
Author(s) -
PHILIPSON KENNETH D.,
NICOLL DEBORA A.,
OTTOLIA MICHELA,
QUEDNAU BEATE D.,
REUTER HANNES,
JOHN SCOTT,
QIU ZHIYONG
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04708.x
Subject(s) - ion exchange , molecule , chemistry , sodium calcium exchanger , topology (electrical circuits) , ion , crystallography , sodium , organic chemistry , engineering , electrical engineering
A bstract : An overview of the molecular physiology of the Na + /Ca 2+ exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na + /Ca 2+ exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.