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Dynamic Localization/Association of Protein Kinase CK2 Subunits in Living Cells
Author(s) -
MARTEL VÉRONIQUE,
FILHOL ODILE,
NUEDA ARSENIO,
COCHET CLAUDE
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04648.x
Subject(s) - protein subunit , phosphorylation , association (psychology) , in vitro , microbiology and biotechnology , kinase , protein kinase a , recombinant dna , chemistry , biology , biochemistry , gene , psychology , psychotherapist
A bstract : Accumulating evidence indicates that in addition to the classical complex, the catalytic and regulatory subunits of CK2 can also exist as free populations in living cells. The association of recombinant CK2 subunits in vitro has been characterized, providing evidence for the first time for their targeted interactions in living cells. The data also suggest that the regulation by phosphorylation of many CK2 substrates may strongly depend on the dynamic localization/association of its subunits.