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Cytokine Induction in Murine Bladder Tissue by Type 1 Fimbriated Escherichia coli
Author(s) -
CARBONE M.,
HASTY D. L.,
YI K. C.,
RUE J.,
FERA M. T.,
TORRE F.,
GIAN M.,
LOSI E.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04127.x
Subject(s) - cytokine , escherichia coli , immune system , tumor necrosis factor alpha , microbiology and biotechnology , biology , epithelium , immunology , pathogen , interleukin , gene , biochemistry , genetics
A bstract : The local cytokine response to uropathogenic phenotype Escherichia coli KBC211 infection exhibits characteristics of both TH1 and TH2 profiles. Interleukin (IL)‐6, MIP‐2, IL‐12, IL‐18, and tumor necrosis factor‐alpha (TNF‐α) are expressed, but IL‐4, IL‐5, and IL‐10 are also present at low levels. This is clearly a complex response that should be explored more fully. The relative contributions of the bladder epithelium and other cells of the bladder wall should also be determined. Epithelial cytokine responses may be considerable, and because these cells are the first to encounter the pathogen, they will be of great importance in the immune response to pathogenic E. coli .