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Fibrinogen and Its Degradation Products as Thrombotic Risk Factors
Author(s) -
LOWE GORDON D.O.,
RUMLEY ANN
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03544.x
Subject(s) - fibrinogen , fibrin , d dimer , prospective cohort study , medicine , randomized controlled trial , clinical trial , immunology
A bstract : Recent meta‐analyses of prospective studies have shown that plasma levels of both fibrinogen and fibrin D‐dimer are independent predictors of ischemic heart disease. Although at present reported studies using different assays do not show heterogeneity, there is a need for prospective comparison of different assays, as well as for development of standards. Collaborative development of the clinical use of these risk predictors is also required. Finally, the causal significance of the associations of fibrinogen and D‐dimer with thrombotic events remains to be established by randomized controlled trials of reduction in their plasma levels.