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DNA Release by Line‐1 (L1) Retrotransposon Could It Be Possible?
Author(s) -
ALVES GILDA,
KAWAMURA MÁRCIA T.,
NASCIMENTO PATRÍCIA,
MACIEL CARLA,
OLIVEIRA JOSÉ ANTÔNIO,
TEIXEIRA ANSELMO,
CARVALHO MARIA DA GLÓRIA C.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06602.x
Subject(s) - retrotransposon , transposable element , dna , genetics , biology , mechanism (biology) , microbiology and biotechnology , genome , gene , philosophy , epistemology
A bstract : We have verified the presence of line‐1 retrotransposon (L1) in plasma DNA in 15/17 brain tumor (glioma) patients and in 6/6 healthy people by applying PCR amplification of part of the L1 5′ end. The same samples were separately amplified for K‐ras . Results suggested that L1 sequences are circulating throughout the body. We hypothesized the participation of transposable elements such as L1 in a putative DNA release mechanism.