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Effect of Leptin in Platelet and Endothelial Cells: Obesity and Arterial Thrombosis
Author(s) -
MARUYAMA IKURO,
NAKATA MASANORI,
YAMAJI KAZUYO
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb06330.x
Subject(s) - annals , medicine , classics , history
We demonstrated that leptin showed effects on both platelets and endothelial cells through its functional receptor. These effects are the vector to inducing thrombotic tendency. Leptin concentrations used in our experiments correspond to that of leptin in the circulation of obese individuals. Thus we suggest that increased leptin may act as a risk factor for thrombosis in obese individuals.