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Ascorbic Acid, Alcohol, and Environmental Chemicals a
Author(s) -
ZANI V. G.,
BRODFUEHRER J. I.,
SMART R. C.,
SUSICK R. L.
Publication year - 1987
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1987.tb23775.x
Subject(s) - ascorbic acid , chemistry , alcohol , environmental chemistry , biochemistry , radiochemistry , food science
It is apparent through the efforts of a number of investigators that ascorbic acid is involved in the metabolism and detoxification of numerous xenobiotics. Interestingly, the vitamin participates a t a variety of levels, including the important hepatic electron transport systems, i.e., cytochrome P-450 mixed function oxygenase (MFO)’-’’ and flavin-containing monooxygenase ( FMO)’2-24; protection against covalent binding of “reactive intermediates” to macromolecular protein^''^^; and more recently involvement in the metabolism and toxicological consequences of a most commonly used and abused drug, alcohol.s’d1.6’.66 Although the precise biochemical mechanism of the vitamin’s participation at these levels warrants further investigation, the role of ascorbic acid in xenobiotic metabolism may have important consequences.