Premium
TUBELESS GASTRIC ANALYSIS AS A TOOL TO MEASURE GASTRIC SECRETORY ACTIVITY *
Author(s) -
Segal Harry L.
Publication year - 1967
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1967.tb51012.x
Subject(s) - intrinsic factor , gastroenterology , malabsorption , pepsin , medicine , secretion , vitamin b12 , gastric acid , gastric secretion , malignancy , gastric mucosa , activated charcoal , vitamin , gastritis , endocrinology , chemistry , stomach , biochemistry , adsorption , enzyme , organic chemistry
Summary This report discusses the tubeless techniques available to evaluate the capability of the gastric mucosa to secrete acid, pepsinogens, and intrinsic factor. The presence of gastric acid can be determined by proper application of the azure A ion‐exchange resin technique. Pepsinogen and intrinsic factor activity may be inferred from measurement of the urinary pepsinogens and the absorption of an oral dose of radioactive vitamin B 12 with or without added intrinsic factor, respectively. A normal serum vitamin B 12 level may be present in a patient with a recent failure of intrinsic factor secretion: however, a decreased level is suggestive of the absence of intrinsic factor in individuals who have no evidence for malabsorption. The value of the rapid charcoal method developed in Herbert's laboratory for measuring serum vitamin B 12 is discussed. The results of the tubeless tests have clinical significance in the diagnosis of gastritis and vitamin B 12 deficiency, in the management of a patient with a gastric ulcer niche, and in suggesting further studies for early detection of gastric malignancy.