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Preparation of Amino Alcohols Condensed with Carbohydrates: Evaluation of Cytotoxicity and Inhibitory Effect on NO Production
Author(s) -
Corrêa Taís A.,
Reis Elaine F. C.,
Alves Lívia L.,
Alves Caio C. S.,
Castro Sandra B. R.,
Dias Alyria T.,
Taveira Aline F.,
Le Hyaric Mireille,
Couri Mara R. C.,
Ferreira Ana P.,
De Almeida Mauro V.
Publication year - 2010
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2010.01026.x
Subject(s) - nitric oxide , cytotoxicity , chemistry , arabinose , galactose , in vitro , inhibitory postsynaptic potential , derivative (finance) , biochemistry , organic chemistry , stereochemistry , biology , xylose , neuroscience , fermentation , economics , financial economics
This work reports the preparation of several amino alcohols condensed with d ‐arabinose, d ‐glucose, and d ‐galactose derivatives. These compounds were evaluated in vitro for their cytotoxicity and ability to decrease nitric oxide production in J774A.1 cells. Arabinofuranoside derivatives 5a , 5b and 5c showed a significant inhibition of nitric oxide production (>80% at 5 μg/mL), while the galactopyranoside derivative 8d showed a notable nitric oxide inhibitory activity (126% at 0.5 μg/mL).