Premium
Synthesis and Immunosuppressive Activity of Lipophilic Amino Alcohols and Diamines
Author(s) -
Reis Elaine F. C.,
Júnior Celso O. R.,
Alves Lívia L.,
Ferreira Ana Paula,
De Almeida Mauro V.
Publication year - 2008
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2008.00740.x
Subject(s) - in vivo , cytotoxicity , chemistry , in vitro , cell growth , biochemistry , cell , amino acid , pharmacology , biology , microbiology and biotechnology
In this work, we report the preparation and evaluation of the in vitro and in vivo of the immunosuppressive activity of a series of lipophilic amino alcohols and diamines. All compounds were evaluated for inhibition of cell proliferation, cytotoxicity and NO production. Compounds 9 , 12 , 13 , 17 , and 18 did not display inhibition of cell proliferation while decreased NO production. The two most potent compounds, 13 and 17 , submitted to delayed‐type hypersensivity assays showed immunosuppressive activity.