Premium
1‐(Azolyl)‐4‐(aryl)‐phthalazines: Novel Potent Inhibitors of VEGF Receptors I and II †
Author(s) -
Kiselyov Alexander S.,
Semenova Marina,
Semenov Victor V.,
Piatnitski Evgueni L.
Publication year - 2006
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2006.00445.x
Subject(s) - aryl , chemistry , combinatorial chemistry , receptor , stereochemistry , biochemistry , organic chemistry , alkyl
Novel potent derivatives of phthalazine are described as an adenosine triphosphate‐competitive inhibitors of vascular endothelial growth factor receptors I and II. A number of compounds display vascular endothelial growth factor receptor II inhibitory activity reaching that of Vatalanib TM A (IC 50 : <50 n m ) in an homogenous time‐resolved fluorescence enzymatic assay.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom