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Impact of Plasma Exchange on Pharmacokinetic Disposition of Micafungin
Author(s) -
Konishi Hiroki,
Fukushima Keizo,
Saotome Takao,
Hamamoto Tetsu,
Eguchi Yutaka,
Sudo Masatomo,
Sumi Masaki,
Minouchi Tokuzo,
Iga Ikumi,
Yamaji Akira
Publication year - 2010
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2009.00797.x
Subject(s) - micafungin , pharmacokinetics , apheresis , medicine , distribution (mathematics) , volume of distribution , clearance , plasma levels , pharmacology , clearance rate , antifungal , urology , platelet , amphotericin b , mathematical analysis , mathematics , dermatology
Change in the pharmacokinetic disposition of an antifungal agent micafungin (MCFG) by 8‐hour plasma exchange (PE) with 3200 mL replacement was examined in a stem cell transplant recipient. On pharmacokinetic analysis of the time course of the serum concentrations of MCFG, it was determined that PE shortened the elimination half‐life of MCFG from 16.5 hours to 6.3 hours. Total clearance (CL tot ) was increased from 0.366 L/h to 0.932 L/h by PE. PE‐dependent clearance (CL pe ) accounted for approximately two‐thirds of CL tot , and PE was found to contribute to the removal of nearly 40% of the total body store of MCFG. It was confirmed that a significant amount of MCFG was excluded into apheresed plasma waste. In addition, adsorption of MCFG onto plasma‐separating membrane was strongly suggested, because the CL pe exceeded the rate of plasma apheresis and MCFG concentrations in apheresed plasma were lower than those in circulating blood collected at the same time. The marked elimination of MCFG during PE can be explained by its low volume of distribution and high affinity for serum proteins. Judging from these findings as well as those of other reports, MCFG can be considered one of the drugs most susceptible to removal by PE. Our findings suggest that an increment in the regular dose of MCFG would be required at the next administration after PE.