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New Cytotoxic Saponins from Lysimachia davurica Ledeb.
Author(s) -
Tian JingKui,
Zou ZhongMei,
Xu LiZhen,
Yang ShiLin
Publication year - 2006
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/j.1744-7909.2006.00223.x-i1
Subject(s) - chemistry , oleanane , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , triterpene , medicine , alternative medicine , pathology
To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I (compound 1) and E (compound 2) were isolated. Their chemical structures were elucidated as 3β, 16α, 28, 29‐tetrihydroxy‐olean‐12‐en‐3‐O‐β‐D‐glucopyranosyl‐(1→2)‐β‐ D ‐glucuronopyranoside (compound 1) and 3β, 16α, 29‐trihydroxy‐13, 28‐epoxy‐oleanane‐3‐O‐β‐D‐glucopyranosyl‐(1→2)‐β‐D‐glucuronopyranoside (compound 2) on the basis of their one‐ and two‐dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells. (Managing editor: Wei Wang)