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Recognition of HLA ‐ A *24:137 allele in a T aiwanese unrelated bone marrow stem cell donor and the plausible HLA haplotype associated with A *24:137
Author(s) -
Yang K. L.,
Lee S. K.,
Kao R. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01134.x
Subject(s) - haplotype , human leukocyte antigen , allele , biology , genetics , exon , point mutation , microbiology and biotechnology , stem cell , hematopoietic stem cell , typing , haematopoiesis , mutation , gene , antigen
Summary We detected a rare HLA ‐ A *24:137 allele in an unrelated T aiwanese haematopoietic stem cell donor during a routine SBT (sequence‐based typing) HLA typing exercise. The DNA sequence of A *24:137 is identical to the sequence of A *24:02:01:01 in exons 2 and 3 except at codon 21 where CGC was replaced with CAA . The DNA variation caused an amino acid alteration at amino acid residue 21 ( R ‐> Q ). The HLA haplotype in association with A *24:137 may be deduced as A *24:137‐ B *15‐ DRB 1*14. The formation of A *24:137 was probably the result of a nucleotide point mutation involving A *24:02:01:01. It remains to be determined whether A *24:137 is restricted to Taiwanese/Chinese ethnicity.