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Association between the Interleukin 10 −1082G>A polymorphism and coronary heart disease risk in a Caucasian population: a meta‐analysis
Author(s) -
Wang Y.,
Zheng J.,
Liu P.,
Yu X.,
Zhou D.,
Jiang L.,
You Y.,
Zhou Y.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01072.x
Subject(s) - genotype , myocardial infarction , coronary artery disease , medicine , meta analysis , confidence interval , polymorphism (computer science) , oncology , gastroenterology , genetics , biology , gene
Summary Interleukin‐10 (IL‐10) is a cytokine with anti‐inflammatory and B‐cell‐stimulating activity. IL‐10 is expressed in human atherosclerotic plaques and studies have shown the involvement of IL‐10 in the atherosclerotic process. The IL‐10 −1082G/A polymorphism is one of the most commonly studied polymorphisms in this gene because of its association with coronary heart disease (CHD) risks, but previous results have been conflicting. We performed a meta‐analysis using six eligible case–control studies (including 14 data sets) with a total of 5006 patients and 3968 controls to summarize the existing data on the association between the IL‐10 −1082G/A polymorphism and CHD risk. Compared with the common IL‐10 −1082G/A GG genotype, the carriers of variant genotypes ( IL‐10 −1082GA/AA) had a 1.12‐fold elevated risk of CHD (95% CI = 1.01–1.23, P = 0.03) under the dominant genetic model, as estimated using a random effect model. The effect of the IL‐10 −1082G/A polymorphism was further evaluated using stratification analysis. In the three disease of artery studies, with the variant genotypes had a not obvious increased risk of disease of artery (OR = 1.19, 95% CI = 0.98–1.44, P = 0.08) as estimated using a fixed effect model. Similar results were found in the nine myocardial infarction studies (OR = 1.13, 95% CI = 1.00–1.27, P = 0.05). It was also demonstrated that the increased risk of CHD associated with IL‐10 −1082G/A variant genotypes was more pronounced in Caucasians (OR = 1.12, 95% CI = 1.01–1.23, P = 0.03). Our meta‐analysis suggests that the IL‐10 −1082G/A polymorphism genotypes (GA+AA) might be associated with an increased risk of CHD, especially in Caucasians.