Premium
Identification of a novel HLA‐A allele, A*11:60, in a Taiwanese family
Author(s) -
Yang K. L.,
Lee S. K.,
Lin C. C.,
Jiang S.,
Chiu H. M.,
Lin S.,
Chen Y. C.,
Jian Y. F.,
Chen M. J.,
Shyr M. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2011
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00974.x
Subject(s) - exon , allele , genetics , amino acid substitution , nucleotide , microbiology and biotechnology , biology , amino acid , gene , mutation
Summary We report the identification and sequence analysis of a new HLA‐A11* variant, A*11:60 allele, found in a Taiwanese leukaemic patient and his siblings. The novel A*11 variant is identical to A*11:03 in exon 2 but differs from A*11:03 in exon 3 by one nucleotide substitution at position 527 (A→T) causing an amino acid change at codon 152 E (Glu)→V (Val) (GAG→GTG). In comparison with HLA‐A*11:01:01, allele A*11:60 has two nucleotide differences in exon 3: at nt 524 (A→G) (CAT→CGT) and at nt 527 (C→T) (GCG→GTG) leading to two amino acid variations at residues 151 H (His)→R (Arg) and 152 A (Ala)→V (Val).