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Identification of a novel HLA‐DQB1 allele, DQB1*0326, in a College of American Pathologists 2009 survey specimen
Author(s) -
Chen M. J.,
Chu C. C.,
Shyr M. H.,
Lin C. L.,
Lin P. Y.,
Yang K. L.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00947.x
Subject(s) - identification (biology) , allele , human leukocyte antigen , medicine , genetics , biology , gene , antigen , botany
Summary We identified a novel DQB1*0326 allele from a proficiency test sample provided by the College of American Pathologists (CAP) medical society. This novel DQB1 allele was unexpectedly discovered by sequence‐based typing method in an attempt to resolve a discrepant typing result between the CAP survey report and our laboratory report. This novel DQB1 allele is most similar to DQB1*030302 and DQB1*0311. DQB1*0326 has a nucleotide substitution resulting an amino acid change when compared with DQB1*030302 (M to L) and it differs from DQB1*0311 by one nucleotide variation causing an amino acid replacement (A to D).

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