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A discrepancy between serological and molecular typing results led to identification of a novel HLA‐B*57 allele: HLA‐B*5728N
Author(s) -
Cosentini E.,
Frison S.,
Longhi E.,
Mantovani M.,
Luongo V.,
Ciardiello G.,
Bruno P.,
Poli F.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00922.x
Subject(s) - allele , hla b , genetics , human leukocyte antigen , typing , hla a , biology , coding region , serology , hla b antigens , gene , antigen , antibody
Summary Here, we describe the characterisation of a new allelic variant of HLA‐B*57. The novel allele, HLA‐B*5728N, was identified with sequence‐based typing in a Caucasoid family. HLA‐B*5728N, differs from HLA‐B*5701 because of a nucleotide substitution at position 420 (C‐>G) resulting in a coding change from Tyrosine to a stop codon.