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FcεRIα gene ( FCER1A ) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients
Author(s) -
Niwa Y.,
Potaczek D. P.,
Kanada S.,
Takagi A.,
Shimokawa N.,
Ito T.,
Mitsuishi K.,
Okubo Y.,
Tajima M.,
Hobo A.,
Ng W.,
Tsuboi R.,
Ikeda S.,
Ogawa H.,
Okumura K.,
Nishiyama C.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00901.x
Subject(s) - atopic dermatitis , immunoglobulin e , genotype , allele , immunology , gene , receptor , medicine , biology , genetics , antibody
Summary Two promoter polymorphisms of the high‐affinity IgE receptor α‐subunit (FcεRIα) gene ( FCER1A ), −66T>C (rs2251746) and −315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the −315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of −315CT/TT genotype or the −315T allele was significantly higher in those with highly elevated total serum IgE concentrations.