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Toll‐like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis
Author(s) -
Xue Y.,
Zhao Z. Q.,
Wang H. J.,
Jin L.,
Liu C. P.,
Wang Y.,
Li J. C.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2009.00892.x
Subject(s) - tuberculosis , tlr2 , gene , genetics , tlr4 , receptor , biology , population , toll like receptor , immunology , medicine , innate immune system , pathology , environmental health
Summary Polymorphisms of the toll‐like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. Genetic variations were analysed by DNA sequencing. We revealed that these polymorphisms were rare in the southeastern Chinese population and were not associated with susceptibility to TB.