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Novel variations in the signal peptide region of transforming growth factor β1 gene in patients with hepatitis: a brief report from India
Author(s) -
Gupta V.,
Arora R.,
Saha A.,
Dhir A.,
Kar P.,
Bamezai R.
Publication year - 2005
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2005.00499.x
Subject(s) - genotype , virology , hepatitis b virus , transforming growth factor , gene , hepatitis d virus , virus , signal peptide , hepatitis c virus , biology , hepatitis b , medicine , genetics , peptide sequence , hbsag
Summary Genotypic status of the signal peptide region of transforming growth factor β1 (TGF‐β1) showed a significant difference in C/C‐genotype frequency at +29 position (codon 10) between a range of viral hepatitis patients and controls ( P = 0.009, OR = 3.15, CI = 1.29–7.678), contributed by those who were infected with hepatitis B virus (HBV) alone or HBV + hepatitis delta virus (HDV) ( P = 0.003, OR = 5.0, CI = 1.78–13.97).