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SEROLOGICALLY DEFINED Rh DETERMINANTS
Author(s) -
Tippett P.
Publication year - 1990
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1990.tb00878.x
Subject(s) - antigen , serology , epitope , monoclonal antibody , extant taxon , antibody , biology , monoclonal , immunology , virology , microbiology and biotechnology , evolutionary biology
SUMMARY Forty‐six numbered Rh antigens which are detected in serological tests are extant; antigens which were most recently numbered are of high or of low incidence. The identification of high incidence Rh antigens through studies involving cells with rare Rh phenotypes, including Rh null cells, is described briefly. The serological investigations and family studies required to show that a low incidence antigen is an Rh antigen are illustrated by a description of the JAL (Rh48) antigen. Heterogeneity of polymorphic Rh antigens revealed by using monoclonal antibodies (MABS) is demonstrated by consideration of the Rh antigen D. A summary of results of serological tests shows that monoclonal anti‐D antibodies define eight D epitopes. Partial D antigens of the D categories are reassessed in terms of expression of D epitopes.