Premium
Mls DETERMINANTS AND ANTI‐Mls RECEPTORS
Author(s) -
Webb S. R.,
Okamoto A.,
Sprent J.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00413.x
Subject(s) - receptor , t cell receptor , microbiology and biotechnology , biology , computational biology , t cell , biochemistry , immunology , immune system
SUMMARY We review evidence from this laboratory that T cell recognition of Mls a determinants is not controlled solely by the α‐β T cell receptor (TcR) molecule. We propose a model in which Mls a recognition reflects a receptor‐ligand interaction between two sets of complementary accessory molecules, one molecule (Mls a ) being expressed on B cells and the other (the anti‐Mls a receptor) on T cells; this interaction augments recognition of self class II molecules by the TcR. The biological role of Mls molecules might be to facilitate physiological T‐B interaction.