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ANTIBODIES TO HUMAN Ia‐LIKE ANTIGENS AND HETEROLOGOUS ANTI‐HUMAN LYMPHOCYTE SERA
Author(s) -
Wilson B. S.,
Ferrone S.
Publication year - 1981
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1981.tb01067.x
Subject(s) - heterologous , immunogenicity , antigen , antiserum , antibody , immunology , lymphocyte , biology , virology , gene , biochemistry
SUMMARY Serolgoical and immunochemical assays detected antibodies to human la‐like antigens in five out of five rabbit antisera to cultured human B lymphoid cells but did not detect them in five bleedings from two rabbits immunized with human peripheral blood lymphocytes. These results, which may reflect differential immunogenicity of la‐like antigens from different cells, indicate that the presence of anti la‐like antibodies in heterologous antihuman lymphocyte sera is not a general phenomenon as reported recently for animal model systems.