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PERSISTENCE OF CYTOTOXIC ANTIBODIES TO HLA‐A,B,C ANTIGENS AND TO Ia‐LIKE ANTIGENS IN PAROUS WOMEN
Author(s) -
Curtoni E. S.,
Pellegrino M. A.,
Indiveri F.,
Borelli I.,
Ferrone S.
Publication year - 1981
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1981.tb00770.x
Subject(s) - antibody , antigen , human leukocyte antigen , immunology , biology , cytotoxic t cell , persistence (discontinuity) , histocompatibility , virology , genetics , in vitro , geotechnical engineering , engineering
Summary Cytotoxic antibodies to HLA‐A,B,C and to Ia‐like antigens were detected in about 8% of sera drawn from 1312 women several years after their last pregnancy. In the majority of sera anti Ia‐like antigen antibodies were not associated with anti HLA‐A,B,C antibodies. Persistence of both types of antibodies was not correlated with the number of pregnancies and with the time interval between the last immunizing stimulus and the drawing of the sample. Testing of the sera with a panel of HLA typed lymphocytes identified 20 sera specific for HLA‐A,B alloantigens and 7 specific for Ia‐like alloantigens.