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SHORT COMMUNICATION : EVIDENCE FOR AN H‐2‐LINKED Ir GENE REGULATING THE IMMUNE RESPONSE TO A TI‐2 ANTIGEN, DNP‐FICOLL
Author(s) -
Schott C. F.,
Lizzio Elaine F.,
Merchant B.
Publication year - 1981
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1981.tb00762.x
Subject(s) - congenic , ficoll , immune system , antigen , gene , immunology , biology , microbiology and biotechnology , chemistry , genetics , peripheral blood mononuclear cell , in vitro
Summary Various H‐2 congenic mouse pairs were immunized with 10 μg of DNP 53 ‐Ficoll, a thymic independent (TI‐2) antigen. Four‐day primary splenic immune responses were measured by a DNP‐reactive PFC assay. Significantly different responses were noted between partners of many congenic pairs. An H‐2‐linked Ir gene for DNP‐Ficoll appears likely.