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NON‐H‐2‐LINKED GENETIC CONTROL OF RESISTANCE TO BALB/c FIBROSARCOMA METH‐A
Author(s) -
Mizushima Y.,
Sendo F.,
Takeichi N.,
Kobayashi H.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00740.x
Subject(s) - meth , fibrosarcoma , resistance (ecology) , chemistry , biology , genetics , organic chemistry , polymer , monomer , acrylate , ecology
Summary The genetic control of hybrid resistance to BALB/c fibrosarcoma Meth‐A was investigated. A Meth‐A tumour grew slower in (BALB/c X C57BL/6)F 1 and reciprocal hybrid mice than in syngeneic BALB/c mice and was also found to grow slower in females than in males. Significant F 1 resistance was demonstrated after both subcutaneous and intraperitoneal injection of tumour cells. However, (BALB/c X DBA/2)F 1 mice did not show any significant resistance to Meth‐A. In H‐2 linkage studies of [BALB/c X (BALB/c X C57BL/6)] backcross mice, no statistically significant differences in the resistance of H‐2 heterozygotes and homozygotes to Meth‐A were observed. These results indicated that F 1 hybrid resistance to Meth‐A was controlled by non‐H‐2‐linked resistance factor(s). No linkage was observed between resistance to Meth‐A and coat colour c‐ and b‐loci.