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Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases
Author(s) -
Baillie George S.
Publication year - 2009
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2009.06926.x
Subject(s) - compartmentalization (fire protection) , phosphodiesterase , second messenger system , effector , microbiology and biotechnology , signalling , biology , function (biology) , pde10a , action (physics) , extracellular , intracellular , biochemistry , enzyme , physics , quantum mechanics
cAMP is the original second messenger that is synthesized in response to a number of extracellular stimuli. Recent advances in cAMP reporter technology have given an insight into how cAMP signals retain their specificity. Spatial and temporal cAMP dynamics are regulated by discretely positioned phosphodiesterases that act as sinks to create simultaneous, multiple cAMP gradients in many cellular locations. Such gradients are sampled within microdomains that contain anchored cAMP effector proteins. Compartmentalization of proteins that produce, degrade and are activated by cAMP is crucial for the specificity of action required for normal cell function.