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Chemical approaches to mapping the function of post‐translational modifications
Author(s) -
Gamblin David P.,
van Kasteren Sander I.,
Chalker Justin M.,
Davis Benjamin G.
Publication year - 2008
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/j.1742-4658.2008.06347.x
Subject(s) - posttranslational modification , proteome , computational biology , protein function , function (biology) , computer science , chemistry , biology , bioinformatics , microbiology and biotechnology , biochemistry , gene , enzyme
Strategies for the chemical construction of synthetic proteins with precisely positioned post‐translational modifications or their mimics offer a powerful method for dissecting the complexity of functional protein alteration and the associated complexity of proteomes.