Open AccessComparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non‐diabetic patients with dyslipidaemia: a prospective randomised open‐label study
Author(s) -
Anagnostis P.,
Selalmatzidou D.,
Polyzos S. A.,
Panagiotou A.,
Slavakis A.,
Panagiotidou A.,
Athyros V. G.,
Karagiannis A.,
Mikhailidis D. P.,
Kita M.
Publication year - 2011
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/j.1742-1241.2011.02655.x
Subject(s) - rosuvastatin , medicine , adiponectin , adipokine , endocrinology , atorvastatin , insulin resistance , leptin , rosuvastatin calcium , insulin , quantitative insulin sensitivity check index , insulin sensitivity , obesity
Summary Aims: The impact of statins on glucose metabolism and adipokines remains controversial. We compared the effects of rosuvastatin and atorvastatin on glucose homeostasis, insulin sensitivity (IS), adiponectin and leptin levels as well as systemic inflammation in non‐diabetic patients with dyslipidaemia. Methods: Thirty‐six patients were randomly assigned to 10 mg/day of rosuvastatin ( n = 18) or 20 mg/day of atorvastatin ( n = 18) for 12 weeks. Total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), non‐HDL‐C, triglycerides (TG), fasting plasma glucose, insulin, homeostasis model assessment‐insulin resistance (HOMA‐IR), quantitative IS check index (QUICKI), adiponectin, leptin and high‐sensitivity C‐reactive protein (hsCRP) were measured at baseline and after 4 and 12 weeks. Results: Both statins significantly lowered TC, LDL‐C, non‐HDL‐C and TG compared with baseline. Only rosuvastatin caused a significant reduction in insulin and HOMA‐IR levels (−35%, p = 0.005 and −33%, p = 0.011 respectively) and a significant increase in QUICKI (+11%, p = 0.003) at 12 weeks. In terms of adipokines and hsCRP, no difference was observed after 4 and 12 weeks of treatment with either statin. Conclusions: Rosuvastatin compared with atorvastatin resulted in significant improvements in IS indices. No significant changes in adiponectin, leptin or hsCRP levels were observed at 4 and 12 weeks of treatment with either statin.