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Clinical and histological intercorrelations in pigmented naevi indicating potential melanoma precursor lesions
Author(s) -
LARSEN T. E.,
MOGENSEN S. B.,
HOLME I.
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05282.x
Subject(s) - melanoma , dermatology , medicine , nevus , pathology , atypia , nuclear atypia , clinical history , immunohistochemistry , cancer research
A series of 577 pigmented naevi from an equal number of patients has been studied histopathologically without access to clinical information. Later the histological findings have been compared with clinical information obtained by sending a questionnaire to the patients. The correlations between the many histological and clinical variables have been studied. Patients with a red or fair hair colour, a freckled, easily sunburnt skin type and/or a poor suntanning ability have the tendency to develop irregular and atypical naevi. Histological variables like nuclear atypia, mitoses, lymphocyte reaction, fibrosis and “shoulder”‐phenomenon regarding the growth pattern of naevi are correlated to this delicate skin type. These findings support til theory that irregular and atypical naevi may be potential precursors to malignant melanomas as patients with this skin type belong to the melanoma risk group.