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IMMUNO‐CYTO‐CHEMICAL STAINING OF MID‐GUT CARCINOID TUMOURS WITH SEQUENCE‐SPECIFIC GASTRIN ANTISERA
Author(s) -
WILANDER E.,
ELSALHY M.
Publication year - 1981
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1981.tb00217.x
Subject(s) - gastrin , antiserum , staining , sequence (biology) , biology , pathology , medicine , antibody , endocrinology , biochemistry , immunology , secretion
Twenty typical mid‐gut carcinoid tumours were examined for the presence of gastrin immuno‐reactivity to antisera specific to the C‐terminal pentapeptide or to the mid‐portion of gastrin‐17. Pentagastrin immuno‐reactivity was found in seven cases, and in one of these reactivity to antiserum against the mid‐portion of gastrin‐17 was also observed. The results are in accordance with the previous observation that argyrophil tumour cells are present in mid‐gut carcinoid tumours and may explain why peptic ulcer disease is sometimes seen in association with the carcinoid syndrome.